Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.34 |
| ▸ | CHRNG | P07510 | 2/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRND | Q07001 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11247440 | 0.90 | HSP90AA1 (0.35) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL11245526 | 0.90 | HMOX1 (0.38) | HMOX1SLC6A2SLC6A4SLC6A3CHRNA1 | |
| SCHEMBL11241770 | 0.89 | GRIN1 (0.39) | — | |
| SCHEMBL11242089 | 0.87 | CHRNA1 (0.35) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL11234350 | 0.86 | HMOX1 (0.36) | HMOX1SLC6A2SLC6A4SLC6A3CHRNA1 | |
| SCHEMBL2082286 | 0.82 | GRIN1 (0.41) | HMOX1SLC6A2SLC6A4SLC6A3CHRNA1 | |
| SCHEMBL11256266 | 0.80 | SLC6A2 (0.32) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| SCHEMBL11251340 | 0.79 | HSP90AA1 (0.37) | HMOX1SLC6A2SLC6A4SLC6A3CHRNA1 | |
| SCHEMBL28604802 | 0.79 | CHRNA1 (0.37) | HMOX1SLC6A2SLC6A4SLC6A3CHRNA1 | |
| SCHEMBL28604796 | 0.79 | CHRNA1 (0.37) | HMOX1SLC6A2SLC6A4SLC6A3CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |