Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11247100 | 0.86 | MKNK2 (0.48) | P2RX7PRMT5WDR77GSK3BMKNK1 | |
| SCHEMBL11243204 | 0.85 | DHODH (0.50) | PRMT5WDR77ALPLMKNK1MKNK2 | |
| SCHEMBL11239797 | 0.82 | POLB (0.44) | PRMT5WDR77KDM4E | |
| SCHEMBL11245576 | 0.78 | PRMT5 (0.49) | PRMT5WDR77MKNK1MKNK2KDM4E | |
| SCHEMBL11242946 | 0.76 | CYP2D6 (0.53) | PRMT5WDR77GSK3BKDM4E | |
| SCHEMBL11243069 | 0.75 | GSK3B (0.43) | ALPLGSK3BKDM4E | |
| SCHEMBL1750449 | 0.74 | GSK3B (0.61) | GSK3BKDM4E | |
| SCHEMBL11241703 | 0.73 | MAPT (0.42) | GSK3BKDM4E | |
| SCHEMBL113365 | 0.72 | P2RX7 (1.00) | P2RX7MKNK1MKNK2KDM4E | |
| SCHEMBL23529762 | 0.71 | NPC1 (0.57) | PRMT5WDR77MKNK1MKNK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |