Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11118932 | 0.85 | PDE3B (0.57) | PDE3BPDE3AGSK3BAURKBINCENP | |
| SCHEMBL11228691 | 0.84 | PDE3B (0.59) | PDE3BPDE3AGSK3BAURKBINCENP | |
| SCHEMBL11242743 | 0.82 | PDE3B (0.54) | PDE3BPDE3AGSK3BAURKBINCENP | |
| SCHEMBL11226186 | 0.81 | PDE3A (0.86) | PDE3BPDE3AGSK3BAURKBINCENP | |
| SCHEMBL11227656 | 0.81 | PDE3B (0.53) | PDE3BPDE3AGSK3BAPLNRCDK5 | |
| SCHEMBL11228419 | 0.80 | PDE3B (0.50) | PDE3BPDE3AGSK3BAURKBINCENP | |
| SCHEMBL11235747 | 0.80 | PDE3B (0.55) | PDE3BPDE3AGSK3BAURKBINCENP | |
| SCHEMBL11229942 | 0.80 | PDE3B (0.58) | PDE3BPDE3AGSK3BAURKBINCENP | |
| SCHEMBL11228371 | 0.80 | PDE3B (0.52) | PDE3BPDE3AGSK3BAURKBINCENP | |
| SCHEMBL11246399 | 0.80 | PDE3B (0.52) | PDE3BPDE3AGSK3BAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |