SCHEMBL1123679

SCHEMBL1123679

O=C(N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O)c1ccc(OCc2cccc(Br)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GPR132 Q9UNW8 6/20 0.67
PTPN1 P18031 2/20 0.59
GPR34 Q9UPC5 4/20 0.58
FFAR1 O14842 1/20 0.57
FFAR4 Q5NUL3 1/20 0.57
PPARG P37231 3/20 0.56
MAOB P27338 1/20 0.56
PARP15 Q460N3 1/20 0.56
PARP14 Q460N5 1/20 0.56
PARP10 Q53GL7 1/20 0.56
CMKLR2 P46091 1/20 0.56
CMKLR1 Q99788 1/20 0.56
ITGB3 P05106 1/20 0.55
ITGA2B P08514 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27658953 1.00 GPR132 (0.67) GPR132PTPN1GPR34FFAR1FFAR4
SCHEMBL5720743 0.92 GPR132 (0.69) GPR132PTPN1GPR34PPARGCMKLR2
SCHEMBL1123134 0.92 GPR132 (0.71) GPR132PTPN1GPR34PPARGCMKLR2
SCHEMBL1122846 0.92 GPR132 (0.71) GPR132PTPN1GPR34PPARGCMKLR2
SCHEMBL1122708 0.91 GPR132 (0.69) GPR132PTPN1GPR34PPARGITGB3
SCHEMBL1123063 0.91 GAA (0.67) GPR132PTPN1FFAR1FFAR4PPARG
SCHEMBL27638044 0.91 GAA (0.67) GPR132PTPN1FFAR1FFAR4PPARG
SCHEMBL1122875 0.90 GPR132 (0.79) GPR132PTPN1GPR34PPARGCMKLR2
SCHEMBL27658925 0.90 GPR132 (0.79) GPR132PTPN1GPR34PPARGCMKLR2
SCHEMBL1123033 0.90 GPR132 (0.77) GPR132PTPN1GPR34PPARGITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1644321-B1 NEW BENZAMIDES AS PPATY MODULATORS S A L V A T LAB SA (ES) 2011-02-09 EP disclosed
US-20060160894-A1 Benzamides as ppar modulators LABORATORIOS S.A.L.V.A.T.,S.A. (ES) 2006-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160894-A1 Benzamides as ppar modulators PPARD, PPARA, PPARG GPR132 122/4885PTPN1 2708/4885GPR34 166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.