Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237603 | 1.00 | PDE3B (0.51) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11222392 | 0.85 | PDE3B (0.54) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11222395 | 0.85 | PDE3B (0.54) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11224300 | 0.84 | PDE3B (0.57) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11224303 | 0.84 | PDE3B (0.57) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11238639 | 0.81 | PDE3B (0.57) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11232562 | 0.81 | PDE3B (0.51) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11232554 | 0.81 | PDE3B (0.51) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11222397 | 0.78 | ITK (0.55) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11222394 | 0.78 | ITK (0.55) | PDE3BPDE3AAURKBINCENPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |