Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 8/20 | 0.55 |
| ▸ | TTK | P33981 | 5/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.55 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | GPR142 | Q7Z601 | 7/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11222394 | 1.00 | ITK (0.55) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11229145 | 0.85 | TTK (0.51) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11229132 | 0.85 | TTK (0.51) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11223826 | 0.82 | ITK (0.39) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11219764 | 0.82 | CCNC (0.51) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11219760 | 0.82 | CCNC (0.51) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11233683 | 0.81 | ITK (0.41) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11233679 | 0.81 | ITK (0.41) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11251128 | 0.81 | TTK (0.42) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11251113 | 0.81 | TTK (0.42) | ITKTTKAURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | claimed |
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |