Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | ADH5 | P11766 | 7/20 | 0.42 |
| ▸ | TACR3 | P29371 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11235491 | 0.85 | PDE3B (0.59) | PDE3BPDE3ARAB9AKDM4EHPGD | |
| SCHEMBL11233155 | 0.84 | CYP11B1 (0.46) | CYP11B1CYP11B2PDE3BPDE3AADH5 | |
| SCHEMBL11235886 | 0.80 | PDE3B (0.46) | CYP11B1CYP11B2PDE3BPDE3AKDM4E | |
| SCHEMBL11231551 | 0.80 | AURKB (0.51) | CYP11B1CYP11B2PDE3BPDE3AKDM4E | |
| SCHEMBL11229699 | 0.78 | PDE3B (0.43) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11234641 | 0.78 | PDE3B (0.44) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11230309 | 0.77 | MKNK1 (0.49) | CYP11B1CYP11B2PDE3BPDE3AKDM4E | |
| SCHEMBL11231128 | 0.77 | MKNK1 (0.49) | PDE3BPDE3A | |
| SCHEMBL10707484 | 0.77 | PDE3B (0.73) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11227650 | 0.75 | PDE3B (0.60) | CYP11B1CYP11B2PDE3BPDE3ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |