Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11235491 | 0.85 | PDE3B (0.59) | PDE3BPDE3ACDC7LMNAHPGD | |
| SCHEMBL11236017 | 0.80 | MAPK1 (0.49) | PDE3BPDE3ACCNCCDK8CDC7 | |
| SCHEMBL11238599 | 0.80 | PDE3B (0.49) | PDE3BPDE3ACCNCCDK8CDC7 | |
| SCHEMBL11237609 | 0.78 | CYP11B1 (0.43) | PDE3BPDE3ACYP3A4HPGDKDM4E | |
| SCHEMBL11243508 | 0.77 | PDE3B (0.43) | PDE3BPDE3ACCNCCDK8CDC7 | |
| SCHEMBL11241422 | 0.77 | PDE3B (0.43) | PDE3BPDE3ACCNCCDK8CDC7 | |
| SCHEMBL11223772 | 0.77 | PDE3A (0.73) | PDE3BPDE3ALMNACYP3A4HPGD | |
| SCHEMBL11244158 | 0.76 | CCNC (0.49) | PDE3BPDE3ACCNCCDK8CDC7 | |
| SCHEMBL11231124 | 0.76 | GRIA1 (0.39) | CCNCCDK8CDC7ROCK2MAP4K4 | |
| SCHEMBL11227650 | 0.75 | PDE3B (0.60) | PDE3BPDE3ACDC7GSK3BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |