Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10987532 | 1.00 | LMNA (0.36) | LMNATSHRHCAR2KDM4EAKR1C1 | |
| SCHEMBL10659448 | 0.75 | AKR1C1 (0.48) | LMNAAKR1C1OPRM1ALDH1A1KMT2A | |
| SCHEMBL994596 | 0.75 | AKR1C1 (0.48) | LMNAAKR1C1OPRM1ALDH1A1KMT2A | |
| SCHEMBL435512 | 0.75 | AKR1C1 (0.48) | LMNAAKR1C1OPRM1ALDH1A1KMT2A | |
| SCHEMBL7414855 | 0.74 | AKR1C1 (0.42) | LMNATSHRHCAR2KDM4EAKR1C1 | |
| Hydrochloric Acid SCHEMBL8114401 | 0.73 | AKR1C1 (0.47) | LMNAAKR1C1OPRM1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL8114403 | 0.73 | AKR1C1 (0.47) | LMNAAKR1C1OPRM1ALDH1A1KMT2A | |
| SCHEMBL11230101 | 0.72 | AKR1C1 (0.32) | HCAR2AKR1C1 | |
| SCHEMBL16057460 | 0.70 | AKR1C1 (0.52) | LMNAAKR1C1OPRM1KMT2AL3MBTL1 | |
| SCHEMBL11241224 | 0.70 | AKR1C1 (0.40) | AKR1C1HDAC3HDAC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316905-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |