Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11247724 | 0.85 | PIK3CD (0.44) | GSK3AGSK3BPRKACACDK8CLK2 | |
| SCHEMBL7284439 | 0.85 | PRKCH (0.46) | GSK3AGSK3BPRKACACDK8CLK2 | |
| SCHEMBL7291065 | 0.85 | ROCK1 (0.46) | GSK3AGSK3BPRKACACDK8CLK2 | |
| SCHEMBL7284179 | 0.84 | GLA (0.42) | GSK3AGSK3BPRKACACDK8CLK2 | |
| SCHEMBL7292117 | 0.84 | ROCK1 (0.43) | GSK3AGSK3BPRKACACDK8CLK2 | |
| SCHEMBL7283041 | 0.83 | CLK4 (0.39) | GSK3AGSK3BPRKACACDK8CLK2 | |
| SCHEMBL6369146 | 0.83 | KDM4E (0.42) | GSK3AGSK3BPRKACACDK8CLK2 | |
| SCHEMBL7293503 | 0.82 | PRKCD (0.48) | GSK3AGSK3BPRKACACDK8CLK2 | |
| SCHEMBL4590900 | 0.82 | KDM4E (0.55) | GSK3AGSK3BCLK4ALDH1A1KDM4E | |
| SCHEMBL7292623 | 0.81 | PRKCD (0.44) | GSK3AGSK3BPRKACACDK8CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362734-A | 2-(Substituted-amino)-5-(pyridinyl-nicotinonitriles, and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |