Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293503 | 0.92 | PRKCD (0.48) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| SCHEMBL7292623 | 0.91 | PRKCD (0.44) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| SCHEMBL7282998 | 0.88 | LATS1 (0.49) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| SCHEMBL7284439 | 0.86 | PRKCH (0.46) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| SCHEMBL11238008 | 0.85 | GSK3A (0.45) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| Fumaric Acid SCHEMBL7482923 | 0.84 | PRKCA (0.42) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| SCHEMBL7292117 | 0.83 | ROCK1 (0.43) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| SCHEMBL9695373 | 0.83 | CCNA2 (0.41) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| Cadaverine Tartrate SCHEMBL7483516 | 0.83 | PRKCA (0.41) | ROCK1CLK2GSK3BDYRK1ACLK4 | |
| SCHEMBL4590994 | 0.83 | HSD17B10 (0.48) | CLK4ALDH1A1KDM4EUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200024-B1 | 3-CYANO-PYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| EP-0200024-A2 | 3-Cyano-pyridines, process for their preparation and their pharmaceutical use | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1986-11-05 | — | — | EP | disclosed |