Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11232434 | 0.99 | GSK3B (0.49) | GSK3BRETCYP3A4CYP2D6CDC7 | |
| SCHEMBL11234436 | 0.95 | GSK3B (0.50) | GSK3BCYP3A4CYP2D6CDC7ROCK2 | |
| SCHEMBL11229632 | 0.90 | GSK3B (0.52) | GSK3BCYP3A4CYP2D6CDC7ROCK2 | |
| SCHEMBL11235570 | 0.85 | GSK3B (0.51) | GSK3BCYP3A4MAP4K4AURKATTK | |
| SCHEMBL11234009 | 0.85 | GSK3B (0.47) | GSK3BRETCYP3A4CDC7ROCK2 | |
| SCHEMBL11252715 | 0.83 | LATS1 (0.36) | GSK3BCYP3A4CYP2D6ROCK2ICMT | |
| SCHEMBL11244896 | 0.83 | GSK3B (0.49) | GSK3BROCK2MAP4K4AURKATTK | |
| SCHEMBL11229155 | 0.82 | GSK3B (0.47) | GSK3BCYP3A4CYP2D6CDC7ROCK2 | |
| SCHEMBL11226000 | 0.82 | GSK3B (0.49) | GSK3BCYP3A4MAP4K4AURKATTK | |
| SCHEMBL11236377 | 0.81 | GSK3B (0.48) | GSK3BCYP3A4MAP4K4AURKATTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |