Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11229632 | 0.87 | GSK3B (0.52) | GSK3BCHEK2MAPK1NTRK1PDGFRB | |
| SCHEMBL11233480 | 0.86 | GSK3B (0.52) | GSK3BCHEK2MAPK1NTRK1PDGFRB | |
| SCHEMBL11236115 | 0.85 | PIK3CB (0.46) | GSK3BIKBKETBK1MAPK1KDR | |
| SCHEMBL11236377 | 0.85 | GSK3B (0.48) | GSK3BIKBKETBK1CHEK2MAPK1 | |
| SCHEMBL11234436 | 0.85 | GSK3B (0.50) | GSK3BCHEK2MAPK1NTRK1PDGFRB | |
| SCHEMBL11235570 | 0.84 | GSK3B (0.51) | GSK3BCHEK2MAPK1NTRK1PDGFRB | |
| SCHEMBL11232434 | 0.84 | GSK3B (0.49) | GSK3BROCK2AURKATTKAURKB | |
| SCHEMBL11226000 | 0.84 | GSK3B (0.49) | GSK3BIKBKETBK1MAPK1NTRK1 | |
| SCHEMBL11361765 | 0.83 | GSK3B (0.42) | GSK3BCHEK2MAPK1NTRK1PDGFRB | |
| SCHEMBL11238191 | 0.83 | GSK3B (0.48) | GSK3BROCK2AURKATTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | claimed |
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |