Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22789784 | 0.87 | KDM4E (0.42) | KDM4ECYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL11151363 | 0.85 | DDB1 (0.58) | KDM4ECYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL563228 | 0.83 | TSHR (0.42) | KDM4ECYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL11153483 | 0.81 | GRIK1 (0.45) | KDM4ECYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL11155638 | 0.79 | POLB (0.43) | KDM4ECYP1A2CYP2C19POLBSMN1; SMN2 | |
| SCHEMBL11389304 | 0.78 | MEN1 (0.51) | CYP1A2HPGDALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL11238679 | 0.78 | KDM4E (0.48) | KDM4ECYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL9417243 | 0.76 | DDB1 (0.47) | KDM4ECYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL11168543 | 0.75 | KDM4E (0.49) | KDM4ECYP1A2HPGDALDH1A1MAPT | |
| SCHEMBL20561976 | 0.74 | EPHX2 (0.58) | KDM4ECYP1A2HPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003084-B1 | SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Takeda Chemical Industries, Ltd. (JP) | 1982-02-24 | — | — | EP | disclosed |
| US-4284644-A | Spirobenzofuranone compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-08-18 | — | — | US | disclosed |