Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9716912 | 0.80 | MEN1 (0.43) | SMN1; SMN2HTTMEN1KMT2AKDM4E | |
| SCHEMBL4258978 | 0.78 | HTT (0.45) | SMN1; SMN2HTTMEN1KMT2AKDM4E | |
| SCHEMBL18774372 | 0.77 | MEN1 (0.44) | SMN1; SMN2HTTMEN1KMT2AKDM4E | |
| SCHEMBL3677590 | 0.75 | HTT (0.42) | SMN1; SMN2HTTKMT2AKDM4EALDH1A1 | |
| SCHEMBL14621784 | 0.73 | KMT2A (0.50) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL9332702 | 0.72 | MEN1 (0.41) | SMN1; SMN2HTTMEN1KMT2AKDM4E | |
| SCHEMBL9332695 | 0.72 | MEN1 (0.38) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL28360789 | 0.71 | PABPC1 (0.42) | MEN1KMT2AKDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL5562270 | 0.70 | KMT2A (0.50) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| Bromide SCHEMBL10553531 | 0.69 | MEN1 (0.42) | MEN1KMT2AALDH1A1RCE1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4315005-A | Cephalosporin antibiotics | GLAXO GROUP LIMITED (GB) | 1982-02-09 | — | — | US | disclosed |