Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233209 | 0.92 | ALDH1A1 (0.71) | ALDH1A1KMT2AGLAKDM4EMAPT | |
| SCHEMBL11240204 | 0.90 | ALDH1A1 (0.66) | ALDH1A1KMT2AACHEGLAKDM4E | |
| SCHEMBL11229781 | 0.90 | ALDH1A1 (0.66) | ALDH1A1KMT2AACHEGLAKDM4E | |
| SCHEMBL11309055 | 0.90 | ALDH1A1 (0.66) | ALDH1A1KMT2AGLAKDM4EMAPT | |
| SCHEMBL11240160 | 0.90 | ALDH1A1 (0.66) | ALDH1A1KMT2AACHEGLAKDM4E | |
| SCHEMBL11258267 | 0.89 | ALDH1A1 (0.62) | ALDH1A1KMT2AACHEGLAKDM4E | |
| SCHEMBL11343383 | 0.88 | AVPR1A (0.56) | ALDH1A1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL11233886 | 0.86 | ALDH1A1 (0.66) | ALDH1A1KMT2AACHEGLAKDM4E | |
| SCHEMBL11321191 | 0.82 | AVPR1A (0.56) | ALDH1A1KMT2AKDM4EMAPTDRD2 | |
| SCHEMBL5173574 | 0.81 | ALDH1A1 (0.97) | ALDH1A1KMT2AGLAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |