Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050698 | 0.80 | MEN1 (0.46) | CYP11B2CYP11B1HRH3 | |
| SCHEMBL26847505 | 0.80 | CYP11B2 (0.46) | CYP11B2CYP11B1CYP2A6 | |
| SCHEMBL11233206 | 0.78 | CYP11B2 (0.45) | CYP11B2CYP11B1ACVR1CYP2A6 | |
| SCHEMBL30567665 | 0.78 | CYP11B2 (0.44) | CYP11B2CYP11B1CYP2A6 | |
| SCHEMBL25407826 | 0.78 | CYP11B2 (0.44) | CYP11B2CYP11B1CYP2A6 | |
| SCHEMBL4061767 | 0.77 | CYP2A6 (0.50) | HRH3CYP2A6 | |
| SCHEMBL13744209 | 0.76 | MKNK1 (0.54) | CYP11B2CYP11B1CYP2A6 | |
| SCHEMBL11249351 | 0.75 | HRH3 (0.46) | HRH3 | |
| SCHEMBL11231804 | 0.74 | HRH3 (0.51) | HRH3 | |
| SCHEMBL15262387 | 0.72 | HRH3 (0.43) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |