SCHEMBL11242371

SCHEMBL11242371

ON=C(c1ccccc1)n1ccnc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.42
CYP3A4 P08684 2/20 0.40
FAAH O00519 1/20 0.38
MGLL Q99685 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
USP2 O75604 1/20 0.38
LMNA P02545 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
TBXAS1 P24557 2/20 0.37
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
CYP11B1 P15538 2/20 0.37
CYP11B2 P19099 2/20 0.37
CYP1A2 P05177 1/20 0.37
POLB P06746 1/20 0.37
CYP2D6 P10635 1/20 0.37
MAPT P10636 1/20 0.37
QPCT Q16769 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11242350 1.00 CYP19A1 (0.42) CYP19A1CYP3A4FAAHMGLLMEN1
SCHEMBL11238039 0.83 NOTUM (0.43) CYP19A1CYP11B1CYP11B2MAPTTSHR
SCHEMBL11238043 0.83 NOTUM (0.43) CYP19A1CYP11B1CYP11B2MAPTTSHR
SCHEMBL11237337 0.77 SMN1; SMN2 (0.44) CYP3A4LMNACYP1A2POLBMAPT
SCHEMBL27857452 0.77 CYP3A4 (0.45) CYP19A1CYP3A4FAAHMGLLMEN1
SCHEMBL11237336 0.77 SMN1; SMN2 (0.44) CYP3A4LMNACYP1A2POLBMAPT
SCHEMBL1424751 0.74 CYP19A1 (0.47) CYP19A1CYP3A4FAAHMGLLMEN1
SCHEMBL13876624 0.74 CYP19A1 (0.63) CYP19A1CYP3A4FAAHMGLLMEN1
SCHEMBL9394293 0.73 CYP19A1 (0.37) CYP19A1CYP11B1CYP11B2
SCHEMBL9394297 0.73 CYP19A1 (0.37) CYP19A1CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-86102906-A Preparation 1, the method for the two substituted imidazole  salt of 3- 1987-02-11 CN disclosed
US-4359469-A Combating pests with N-sulphenylated oxime-carbamates BAYER AKTIENGESELLSCHAFT (DE) 1982-11-16 US disclosed