Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.46 |
| ▸ | BACE1 | P56817 | 6/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29116647 | 0.74 | CYP19A1 (0.50) | GRM4BACE1BACE2CYP19A1MEN1 | |
| SCHEMBL11480980 | 0.74 | POLB (0.57) | ARMEN1KMT2AALDH1A1BCHE | |
| Methsuximide SCHEMBL34852 | 0.73 | CYP19A1 (0.70) | GRM4BACE1BACE2CYP19A1MEN1 | |
| Methsuximide SCHEMBL34853 | 0.73 | CYP19A1 (0.70) | GRM4BACE1BACE2CYP19A1MEN1 | |
| SCHEMBL10855612 | 0.71 | ALDH1A1 (0.51) | BACE1ARMEN1KMT2AALDH1A1 | |
| SCHEMBL14037658 | 0.69 | CYP19A1 (0.47) | BACE1BACE2CYP19A1CYP2C19LMNA | |
| SCHEMBL11249870 | 0.69 | ALDH1A1 (0.43) | GRM4ARALDH1A1BCHESMN1; SMN2 | |
| SCHEMBL13684394 | 0.69 | CYP19A1 (0.44) | GRM4BACE1CYP19A1MEN1KMT2A | |
| SCHEMBL11930003 | 0.69 | CYP19A1 (0.44) | GRM4BACE1CYP19A1MEN1KMT2A | |
| SCHEMBL6055400 | 0.68 | ALDH1A1 (0.50) | BACE1MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309541-A | CHEMICAL INTERMEDIATES TO QUINAZOLINE HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4255429-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |