Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243290 | 1.00 | F2RL3 (0.48) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11247678 | 0.88 | SMN1; SMN2 (0.51) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11247680 | 0.88 | SMN1; SMN2 (0.51) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11233168 | 0.87 | POLB (0.48) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11233159 | 0.87 | POLB (0.48) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11243022 | 0.85 | MMP9 (0.50) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11243025 | 0.85 | MMP9 (0.50) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11246428 | 0.83 | F2RL3 (0.46) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11246433 | 0.83 | F2RL3 (0.46) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11250718 | 0.82 | SMN1; SMN2 (0.44) | F2RL3SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4246269-A | Antidepressant piperidinones | CIBA-GEIGY CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |