Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 3/20 | 0.49 |
| ▸ | CDK8 | P49336 | 3/20 | 0.49 |
| ▸ | CDC7 | O00311 | 5/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243508 | 0.89 | PDE3B (0.43) | CCNCCDK8CDC7PIK3CBPDE3B | |
| SCHEMBL11236049 | 0.87 | CCNC (0.41) | CCNCCDK8CDC7PIK3CBPDE3B | |
| SCHEMBL11084198 | 0.85 | CCNC (0.53) | CCNCCDK8CDC7PIK3CBPDE3B | |
| SCHEMBL11078652 | 0.85 | CDC7 (0.61) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL11236041 | 0.83 | PDE3B (0.41) | CCNCCDK8CDC7PIK3CBPDE3B | |
| SCHEMBL11238599 | 0.82 | PDE3B (0.49) | CCNCCDK8CDC7PIK3CBPDE3B | |
| SCHEMBL11236017 | 0.80 | MAPK1 (0.49) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL11231128 | 0.79 | MKNK1 (0.49) | CDC7PDE3BPDE3ABTKMKNK2 | |
| SCHEMBL10996883 | 0.78 | CDC7 (0.43) | CDC7PDE3BPDE3ACDK5CDK5R1 | |
| SCHEMBL11241422 | 0.77 | PDE3B (0.43) | CCNCCDK8CDC7PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |