Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236017 | 0.84 | MAPK1 (0.49) | PDE3BPDE3ACCNCCDK8MTOR | |
| SCHEMBL11232233 | 0.83 | PDE3B (0.66) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL11244158 | 0.82 | CCNC (0.49) | PDE3BPDE3ACCNCCDK8MTOR | |
| SCHEMBL11243508 | 0.81 | PDE3B (0.43) | PDE3BPDE3ACCNCCDK8MAP4K4 | |
| SCHEMBL11241422 | 0.81 | PDE3B (0.43) | PDE3BPDE3ACCNCCDK8MTOR | |
| SCHEMBL11223772 | 0.81 | PDE3A (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11229699 | 0.80 | PDE3B (0.43) | PDE3BPDE3ACCNCCDK8MAP4K4 | |
| SCHEMBL11236049 | 0.79 | CCNC (0.41) | PDE3BPDE3ACCNCCDK8MTOR | |
| SCHEMBL11232466 | 0.79 | MAPK1 (0.46) | PDE3BPDE3ACCNCCDK8MTOR | |
| SCHEMBL11236041 | 0.78 | PDE3B (0.41) | PDE3BPDE3ACCNCCDK8MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4339584-A | Process for preparing 3-amino-5-(pyridinyl)-2(1H)-pyridinones via N-hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide by reaction with polyphosphoric acid | STERLING DRUG INC. (US) | 1982-07-13 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |
| US-4305948-A | N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |