Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.54 |
| ▸ | MERTK | Q12866 | 4/20 | 0.53 |
| ▸ | RAD52 | P43351 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245206 | 0.86 | APP (0.62) | APPMEN1KMT2APDE5ACYP1A2 | |
| SCHEMBL11254689 | 0.85 | MEN1 (0.59) | APPPOLBMEN1KMT2APDE5A | |
| SCHEMBL11250201 | 0.82 | APP (0.63) | APPMEN1KMT2APDE5ACYP1A2 | |
| SCHEMBL11247021 | 0.82 | SMN1; SMN2 (0.66) | APPPOLBKMT2ACYP1A2CYP3A4 | |
| SCHEMBL11254757 | 0.82 | SMN1; SMN2 (0.66) | APPPOLBKMT2ACYP1A2CYP3A4 | |
| SCHEMBL11264671 | 0.82 | SMN1; SMN2 (0.66) | APPPOLBKMT2ACYP1A2CYP3A4 | |
| SCHEMBL2845653 | 0.82 | APP (0.76) | APPMERTKPOLBKMT2APDE5A | |
| SCHEMBL11258102 | 0.82 | SMN1; SMN2 (0.66) | APPPOLBKMT2ACYP1A2CYP3A4 | |
| SCHEMBL11254560 | 0.82 | SMN1; SMN2 (0.66) | APPPOLBKMT2ACYP1A2CYP3A4 | |
| SCHEMBL11244771 | 0.82 | SMN1; SMN2 (0.66) | APPPOLBKMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |