Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 11/20 | 0.76 |
| ▸ | ACP1 | P24666 | 4/20 | 0.58 |
| ▸ | PDE5A | O76074 | 2/20 | 0.56 |
| ▸ | BCHE | P06276 | 5/20 | 0.54 |
| ▸ | ACHE | P22303 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MERTK | Q12866 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685041 | 0.87 | APP (0.74) | APPACP1PDE5APOLB | |
| SCHEMBL17799869 | 0.87 | APP (1.00) | APPPDE5ABCHEACHEKMT2A | |
| Hydrochloric Acid SCHEMBL1685081 | 0.86 | APP (0.72) | APPACP1PDE5AKMT2APOLB | |
| SCHEMBL4865170 | 0.84 | PDE5A (0.76) | ACP1PDE5AKMT2APOLB | |
| SCHEMBL11244506 | 0.82 | APP (0.54) | APPPDE5AKMT2AMERTKPOLB | |
| SCHEMBL18095969 | 0.82 | APP (0.60) | APPACP1PDE5AMERTK | |
| SCHEMBL17800065 | 0.82 | APP (0.84) | APPPDE5ABCHEACHEKMT2A | |
| SCHEMBL23747941 | 0.81 | ACHE (0.63) | APPBCHEACHEKMT2AMERTK | |
| SCHEMBL30125342 | 0.79 | ACHE (0.61) | APPACP1BCHEACHEMERTK | |
| SCHEMBL23723424 | 0.79 | ACHE (0.61) | APPACP1BCHEACHEMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2010056907-A2 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | IAPP, PNLIP, GPR119 | APP 1584/4885ACP1 3341/4885PDE5A 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.