Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245188 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL11245201 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL11238871 | 0.90 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3PRMT5WDR77 | |
| SCHEMBL11238860 | 0.90 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3PRMT5WDR77 | |
| SCHEMBL11238867 | 0.90 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3PRMT5WDR77 | |
| SCHEMBL13389384 | 0.82 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL11248815 | 0.81 | HTR2C (0.51) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL11230923 | 0.81 | HTR2C (0.51) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL11248801 | 0.81 | HTR2C (0.51) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL11230972 | 0.81 | HTR2C (0.51) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4246269-A | Antidepressant piperidinones | CIBA-GEIGY CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |