Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11251464 | 0.99 | HTR2A (0.52) | HTR2AHRH1DRD2NOX1MAPT | |
| SCHEMBL11253567 | 0.85 | L3MBTL1 (0.41) | HTR2AHRH1DRD2MAPTBACE1 | |
| SCHEMBL11243072 | 0.85 | HPGD (0.47) | HTR2AHRH1DRD2NOX1MAPT | |
| Bromide SCHEMBL11253808 | 0.84 | L3MBTL1 (0.41) | HTR2AHRH1DRD2MAPTBACE1 | |
| Bromide SCHEMBL11247249 | 0.84 | HPGD (0.46) | HTR2AHRH1DRD2NOX1MAPT | |
| SCHEMBL3010851 | 0.83 | HTR2A (0.53) | HTR2AHRH1DRD2NOX1MAPT | |
| SCHEMBL11250474 | 0.83 | HTR2A (0.56) | HTR2AHRH1DRD2MAPTGPR84 | |
| Bromide SCHEMBL11256460 | 0.82 | HTR2A (0.56) | HTR2AHRH1DRD2MAPTGPR84 | |
| SCHEMBL3012240 | 0.81 | HTR2A (0.52) | HTR2AHRH1DRD2NOX1MAPT | |
| SCHEMBL11245424 | 0.80 | HTR2A (0.54) | HTR2AHRH1DRD2MAPTGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013424-B1 | SPIRO(DIBENZO(B,F)THIEPINE-PIPERIDINES), INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | claimed |
| EP-0013424-A1 | Spiro(dibenzo(b,f)thiepine-piperidines), intermediate products for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | claimed |
| US-4198420-A | Spiro[dibenz(b,f)thiepin-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | claimed |