Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11253382 | 0.80 | KMT2A (0.43) | MAPTMEN1KMT2AALDH1A1GABRA1 | |
| SCHEMBL2301987 | 0.77 | MAPT (0.38) | MAPTMEN1KMT2AHSP90AA1KDM4E | |
| SCHEMBL11193443 | 0.75 | KDM4E (0.49) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL2301583 | 0.74 | MAPT (0.40) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL28547662 | 0.73 | ALDH1A1 (0.34) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL11057740 | 0.73 | ALDH1A1 (0.41) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL30223478 | 0.73 | CFTR (0.38) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| Acrylic Acid SCHEMBL10706068 | 0.73 | KMT2A (0.38) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12545912 | 0.71 | MEN1 (0.53) | KEAP1SMN1; SMN2MEN1KMT2AHSP90AA1 | |
| SCHEMBL11248250 | 0.67 | TDP1 (0.40) | MAPTSMN1; SMN2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001699-B1 | DERIVATIVES OF FURYL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1982-02-24 | — | — | EP | disclosed |
| US-4288443-A | HISTAMINE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1981-09-08 | — | — | US | disclosed |
| EP-0001699-A2 | Derivatives of furyl compounds, their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1979-05-02 | — | — | EP | disclosed |