Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245712 | 1.00 | ALPG (0.42) | ALPGMEN1KMT2AAKR1B1ALOX5 | |
| SCHEMBL11263153 | 0.91 | ALPG (0.44) | ALPGMEN1KMT2AAKR1B1MAPT | |
| SCHEMBL11263149 | 0.91 | ALPG (0.44) | ALPGMEN1KMT2AAKR1B1MAPT | |
| SCHEMBL11250680 | 0.88 | ALPG (0.42) | ALPGKMT2AAKR1B1MAPTPOLB | |
| SCHEMBL11250685 | 0.88 | ALPG (0.42) | ALPGKMT2AAKR1B1MAPTPOLB | |
| SCHEMBL11249842 | 0.85 | KDM4E (0.41) | ALPGMEN1KMT2AAKR1B1MAPT | |
| SCHEMBL11249851 | 0.85 | KDM4E (0.41) | ALPGMEN1KMT2AAKR1B1MAPT | |
| SCHEMBL11257713 | 0.82 | PTGS1 (0.42) | ALPGAKR1B1ALOX5PTGS1PTGS2 | |
| SCHEMBL11257721 | 0.82 | PTGS1 (0.42) | ALPGAKR1B1ALOX5PTGS1PTGS2 | |
| SCHEMBL11263718 | 0.82 | ALPG (0.47) | ALPGMEN1KMT2AAKR1B1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4341780-A | Substituted pyrido [1,2-a] pyrimidines useful as anti-allergic, anti-ulcer and anti-diabetic agents | FARMITALIA CARLO ERBA S.P.A. (IT) | 1982-07-27 | — | — | US | disclosed |
| US-4310526-A | Substituted 6,7-methylene pyrido[1,2-a]pyrimidines useful as anti-allergic and anti-ulcer agents | FARMITALIA CARLO ERBA S.P.A. (IT) | 1982-01-12 | — | — | US | disclosed |