Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ACP3 | P15309 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6327248 | 0.94 | SLC6A4 (0.55) | SLC6A4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6319526 | 0.94 | SLC6A4 (0.55) | SLC6A4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6320389 | 0.94 | SLC6A4 (0.55) | SLC6A4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7678158 | 0.84 | TAAR1 (0.50) | SLC6A4LMNAMAOAOPRK1 | |
| Fumaric Acid SCHEMBL11241445 | 0.82 | THRB (0.49) | SLC6A4ALDH1A1KMT2ACYP1A2CYP2D6 | |
| Fumaric Acid SCHEMBL11241484 | 0.82 | THRB (0.49) | SLC6A4ALDH1A1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL2065584 | 0.79 | HTR2A (0.64) | SLC6A4ALDH1A1ACP3KMT2AMITF | |
| SCHEMBL3253569 | 0.79 | DPP4 (0.61) | ALDH1A1ACP3PBRM1CYP1A2CYP2D6 | |
| SCHEMBL2153572 | 0.79 | ACP3 (0.56) | ALDH1A1ACP3PBRM1CYP1A2CYP2D6 | |
| SCHEMBL19282953 | 0.79 | ACP3 (0.56) | ALDH1A1ACP3PBRM1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000322-B1 | COMPOUNDS HAVING AN ANTI-DEPRESSIVE OR TRANQUILIZING ACTIVITY, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION | Astra Läkemedel Aktiebolag (SE) | 1982-05-05 | — | — | EP | claimed |
| EP-0000322-A1 | Compounds having an anti-depressive or tranquilizing activity, pharmaceutical compositions containing them, and processes and intermediates for their preparation | Astra Läkemedel Aktiebolag (SE) | 1979-01-10 | — | — | EP | claimed |
| EP-0000322-A1 | Compounds having an anti-depressive or tranquilizing activity, pharmaceutical compositions containing them, and processes and intermediates for their preparation | Astra Läkemedel Aktiebolag (SE) | 1979-01-10 | — | — | EP | disclosed |