Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15700133 | 0.83 | CYP19A1 (0.67) | CYP19A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL31028062 | 0.81 | HTR1A (0.47) | CYP19A1DRD2DRD3DRD4 | |
| SCHEMBL8673224 | 0.81 | CYP19A1 (0.60) | CYP19A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL8875326 | 0.80 | CYP19A1 (0.62) | CYP19A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL3822324 | 0.80 | CYP19A1 (0.62) | CYP19A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL9361537 | 0.80 | MAPT (0.59) | CYP19A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL9343214 | 0.79 | CYP19A1 (0.61) | CYP19A1KDM4ELMNAPOLBMAPT | |
| Hydrochloric Acid SCHEMBL5459542 | 0.79 | CYP19A1 (0.61) | CYP19A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL8671806 | 0.79 | CYP19A1 (0.58) | CYP19A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL8671801 | 0.79 | CYP19A1 (0.58) | CYP19A1KDM4ELMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309345-A | POTASSIUM-SPARING DIURETICS | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4173633-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1979-11-06 | — | — | US | disclosed |