SCHEMBL11247752

SCHEMBL11247752

Cc1cc(C)c(-n2cc(C#N)c(=O)[nH]c2=O)c(C)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.52
L3MBTL1 Q9Y468 1/20 0.51
KMT2A Q03164 5/20 0.50
MEN1 O00255 2/20 0.50
SMN1; SMN2 Q16637 1/20 0.38
KDM4E B2RXH2 6/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 3/20 0.36
POLB P06746 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GALR3 O60755 1/20 0.36
CYP2C19 P33261 2/20 0.35
PDE3B Q13370 2/20 0.35
PDE3A Q14432 2/20 0.35
PDE5A O76074 1/20 0.35
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
PTGS1 P23219 1/20 0.35
PDE4A P27815 1/20 0.35
BLM P54132 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11248770 0.88 GAA (0.50) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11251532 0.88 GAA (0.50) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11255801 0.87 GAA (0.49) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11243558 0.86 L3MBTL1 (0.64) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11245190 0.85 GAA (0.63) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11246266 0.84 GAA (0.49) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11250834 0.81 GAA (0.52) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11236304 0.81 GAA (0.54) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11250343 0.78 GAA (0.49) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11250370 0.78 L3MBTL1 (0.57) GAAL3MBTL1KMT2AMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4358591-A BACTERICIDES, FUNGICIDES; PLANT DISEASES ZOECON CORPORATION (US) 1982-11-09 US disclosed
US-4338318-A FUNGICIDE OR BACERICIDE TO TREAT PLANT DISEASES WITH A PHENYL URACIL ZOECON CORPORATION (US) 1982-07-06 US disclosed
US-4307098-A 2-PHENYL-URACIL COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-12-22 US disclosed
US-4297297-A α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates ZOECON CORP. (US) 1981-10-27 US disclosed
US-4266056-A FUNGICIDES, BACTERICIDES ZOECON CORPORATION (US) 1981-05-05 US disclosed