Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL11247631 | 0.95 | SIRT5 (0.55) | SIRT5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11246181 | 0.88 | MAPT (0.53) | SIRT5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11239265 | 0.88 | MAPT (0.57) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL3608636 | 0.87 | MAPT (0.51) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL11248461 | 0.86 | MAPT (0.55) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL3612694 | 0.84 | MAPT (0.67) | SIRT5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10675056 | 0.83 | MAPT (0.50) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL11253950 | 0.82 | MAPT (0.64) | SIRT5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11245298 | 0.82 | MAPT (0.45) | SIRT5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11245292 | 0.82 | MAPT (0.45) | SIRT5NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4315009-A | Antisecretory guanidine derivatives and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-02-09 | — | — | US | disclosed |
| EP-0003640-A2 | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-08-22 | — | — | EP | disclosed |