SIRT5

NAD-dependent protein deacylase sirtuin-5, mitochondrial · Q9NXA8 · SIRT5 on Sugi Atlas →

49,977 patent compounds predicted against SIRT5, 33,974 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL487145	0.56	6/20
Balsalazide (SCHEMBL118300)	1.00	5/20
Balsalazide (SCHEMBL138311)	1.00	5/20
Balsalazide (SCHEMBL134019)	0.97	5/20
Balsalazide (SCHEMBL133200)	0.95	5/20
Balsalazide (SCHEMBL30360)	0.67	5/20
Balsalazide (SCHEMBL30361)	0.65	5/20
SCHEMBL236067	0.51	5/20
SCHEMBL418900	0.51	5/20
SCHEMBL448179	0.51	5/20
SCHEMBL12126	0.45	5/20
SCHEMBL46214	0.46	4/20
Echinocystic Acid (SCHEMBL42864)	1.00	3/20
Primulagenin (SCHEMBL179854)	0.69	3/20
Aleuritolic Acid (SCHEMBL438408)	0.59	3/20
SCHEMBL420802	0.55	3/20
SCHEMBL446710	0.55	3/20
SCHEMBL446711	0.55	3/20
SCHEMBL381990	0.52	3/20
SCHEMBL468736	0.47	3/20

Clinical trials — most relevant to SIRT5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardiotoxicity in Breast Cancer Patients	PHASE4	RECRUITING
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients	PHASE3	UNKNOWN
Sirtuin-NAD Activator in Alzheimer's Disease	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Oral Nitrite for Older Heart Failure Patients	PHASE2	COMPLETED
Protective Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac Dysfunction	PHASE1/PHASE2	RECRUITING
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age	PHASE2	COMPLETED
NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals	PHASE2	RECRUITING
The Safety and Efficacy of an NAD+ Boosting Product Together With a Low Carbohydrate Diet in Adults With Mild Hypertension and Eligible for Normal-standard-of-care	PHASE2	COMPLETED
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension	PHASE2	NOT_YET_RECRUITING
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors	PHASE1	RECRUITING
Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)	PHASE1	COMPLETED
Sirtuin1 in COVID19 Patients	nan	UNKNOWN
How Sirtuin Levels Change During Behçet Disease	nan	UNKNOWN
Project SIRT6 Activator	nan	RECRUITING
Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery	nan	NOT_YET_RECRUITING
Sirtuin 3 and Sirtuin 7 in Systemic Sclerosis	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Inflammatory Axis and Sirtuins' in Overweight Pre-diabetics Patients	nan	COMPLETED
Comparison of Cardiometabolic Markers in Individuals With Hypertriglyceridemia With Low and High Weight Loss Responses to an Energy-restricted Diet	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
The PRE-OP ENERGY Trial	nan	UNKNOWN
The Effects of Resveratrol on Sirtuins and Apoptosis Biomarkers	nan	UNKNOWN
Short Interval Resveratrol Trial in Cardiovascular Surgery	nan	ACTIVE_NOT_RECRUITING
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
SWE to Detect Enthesitis in PsA: Relationship With SIRT2 Expression and Disease Activity	nan	NOT_YET_RECRUITING
The Safety and Efficacy Study of RiaGev in Healthy Adults	nan	UNKNOWN
Low Sirtuin-1 Levels Are Linked to Erythropoietin Resistance in Hemodialysis Patients.	nan	COMPLETED
Expression of Longevity Genes in Response to Extended Fasting	nan	COMPLETED
Inflammation in COPD and the Effect of Nicotinamide Riboside	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SIRT5 binder may also engage these)

Protein	Name	Similarity
Q5R6G3	—	1.000	Q5R6G3 →
F7EZ75	—	1.000	F7EZ75 →
Q3ZBQ0	—	1.000	Q3ZBQ0 →
E2RDZ6	—	1.000	E2RDZ6 →
F7DKV7	—	1.000	F7DKV7 →
Q68FX9	—	1.000	Q68FX9 →
Q6DHI5	—	0.999	Q6DHI5 →
Q5HZN8	—	0.997	Q5HZN8 →
Q68F47	—	0.997	Q68F47 →
E9GD30	—	0.996	E9GD30 →
E1BRE2	—	0.995	E1BRE2 →
Q5RBF1	—	0.991	Q5RBF1 →
Q2QMG2	—	0.988	Q2QMG2 →
Q83RR8	—	0.987	Q83RR8 →
Q94AQ6	—	0.987	Q94AQ6 →
C5G8R4	—	0.986	C5G8R4 →
Q8K2C6	—	0.986	Q8K2C6 →
Q42523	—	0.986	Q42523 →
P0C585	—	0.986	P0C585 →
P09842	—	0.985	P09842 →
Q5AW69	—	0.985	Q5AW69 →
A9UVV1	—	0.985	A9UVV1 →
Q7UFQ9	—	0.985	Q7UFQ9 →
Q57V41	—	0.985	Q57V41 →
A6R8Q8	—	0.985	A6R8Q8 →
Q8X8E0	—	0.985	Q8X8E0 →
Q9SS48	—	0.985	Q9SS48 →
Q9FE17	—	0.985	Q9FE17 →
P0A2F3	—	0.984	P0A2F3 →
Q5ZHX9	—	0.984	Q5ZHX9 →