Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 2/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25337824 | 0.91 | HTR2C (0.49) | HTR2CHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19030724 | 0.82 | HTR2C (0.43) | HTR2CHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL31236087 | 0.81 | HTR2C (0.49) | HTR2CHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL31235913 | 0.80 | HTR2C (0.40) | HTR2CPNMTASIC3PARP1PARP10 | |
| Hydrochloric Acid SCHEMBL10502741 | 0.78 | HDAC3 (0.44) | HTR2CHDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL10502742 | 0.78 | HDAC3 (0.44) | HTR2CHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11258065 | 0.78 | HTR2C (0.47) | HTR2CHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL863663 | 0.78 | HTR2C (0.46) | HTR2CHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29418152 | 0.78 | OPRD1 (0.43) | HTR2CHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11254844 | 0.78 | OPRD1 (0.43) | HTR2CHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004952-B1 | SPIRO-(DIHYDROBENZOFURANPIPERIDINES AND -PYRROLIDINES) AND DERIVATIVES THEREOF, METHODS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-04-07 | — | — | EP | disclosed |
| EP-0004952-A1 | Spiro-(dihydrobenzofuranpiperidines and -pyrrolidines) and derivatives thereof, methods for their preparation and medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-10-31 | — | — | EP | disclosed |
| US-4166119-A | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines | AMERICAN HOECHST CORPORATION (US) | 1979-08-28 | — | — | US | disclosed |