Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11239088 | 0.93 | CYP11B1 (0.49) | CYP11B1CYP11B2KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL11239243 | 0.89 | CYP11B1 (0.52) | CYP11B1CYP11B2KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL11248555 | 0.89 | CYP11B1 (0.52) | CYP11B1CYP11B2KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL11254885 | 0.89 | CYP11B1 (0.46) | CYP11B1CYP11B2KMT2APOLBCTDSP1 | |
| SCHEMBL11242485 | 0.88 | CYP19A1 (0.43) | CYP11B1CYP11B2KMT2ACYP1A2CYP3A4 | |
| SCHEMBL11242726 | 0.88 | CYP11B1 (0.55) | CYP11B1CYP11B2KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL11249457 | 0.87 | CYP19A1 (0.46) | CYP11B1CYP11B2CYP19A1ALDH1A1 | |
| SCHEMBL11250794 | 0.86 | CYP11B1 (0.53) | CYP11B1CYP11B2KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL11232028 | 0.83 | CYP11B1 (0.50) | CYP11B1CYP11B2 | |
| SCHEMBL11253197 | 0.83 | HMOX1 (0.50) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |