Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRND | Q07001 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879750 | 0.87 | GRIN1 (0.43) | GRIN1GRIN2BCHRNA1CHRNGCHRNB1 | |
| SCHEMBL11250705 | 0.87 | MAOB (0.39) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL28611458 | 0.85 | CHRNA1 (0.41) | GRIN1GRIN2BCHRNA1CHRNGCHRNB1 | |
| SCHEMBL11244135 | 0.84 | GRIN1 (0.44) | GRIN1GRIN2BCHRNA1CHRNGCHRNB1 | |
| SCHEMBL11247712 | 0.84 | MAOB (0.37) | GRIN1GRIN2BCHRNA1CHRNGCHRNB1 | |
| SCHEMBL11234578 | 0.84 | TSHR (0.39) | GRIN1GRIN2BCA12CA1CA2 | |
| SCHEMBL11239184 | 0.84 | CHRNA1 (0.35) | GRIN1GRIN2BCHRNA1CHRNGCHRNB1 | |
| SCHEMBL11243351 | 0.82 | CHRNA1 (0.35) | GRIN1GRIN2BCHRNA1CHRNGCHRNB1 | |
| SCHEMBL11246464 | 0.82 | GRIN1 (0.40) | GRIN1GRIN2BCHRNA1CHRNGCHRNB1 | |
| SCHEMBL11247257 | 0.82 | GRIN1 (0.35) | GRIN1GRIN2BCHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |