Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250705 | 0.94 | MAOB (0.39) | MAOBMAOASIRT2GSK3BALDH1A1 | |
| SCHEMBL10848899 | 0.84 | MAOB (0.41) | MAOBMAOAGSK3BSLC6A4SLC6A3 | |
| SCHEMBL9517524 | 0.84 | MAOB (0.41) | MAOBMAOAGSK3BSLC6A4SLC6A3 | |
| SCHEMBL11248824 | 0.84 | GRIN1 (0.43) | MAOBMAOASIRT2GSK3BGRIN1 | |
| SCHEMBL11239210 | 0.84 | RYR2 (0.35) | MAOBMAOASLC6A4SLC6A3GRIN1 | |
| SCHEMBL11245868 | 0.83 | TSHR (0.42) | CYP2C19ALDH1A1CA12CA1CA2 | |
| SCHEMBL11243674 | 0.83 | MAOB (0.33) | MAOBMAOAGSK3B | |
| SCHEMBL11239617 | 0.82 | SLC6A4 (0.37) | MAOBMAOASLC6A4SLC6A3GRIN1 | |
| SCHEMBL11240325 | 0.80 | SLC6A4 (0.33) | MAOBMAOASIRT2GSK3BSLC6A4 | |
| SCHEMBL11239353 | 0.80 | TSHR (0.38) | GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |