Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 14/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11238693 | 0.82 | PDE3B (0.59) | PDE3BPDE3AGRIN1GRIN2B | |
| SCHEMBL11236623 | 0.78 | GRIN1 (0.55) | GRIN1GRIN2B | |
| SCHEMBL11227373 | 0.76 | GRIN1 (0.57) | GRIN1GRIN2B | |
| SCHEMBL17807828 | 0.76 | MAOB (0.44) | GRIN1GRIN2BPGRMTOR | |
| SCHEMBL19836475 | 0.76 | AURKA (0.42) | GRIN1GRIN2BPGRMTOR | |
| SCHEMBL2507320 | 0.75 | ACVR1 (0.45) | GRIN1GRIN2BPGR | |
| SCHEMBL11230943 | 0.74 | GRIN1 (0.55) | GRIN1GRIN2B | |
| SCHEMBL11237110 | 0.74 | GRIN1 (0.57) | GRIN1GRIN2B | |
| SCHEMBL11233554 | 0.74 | GRIN1 (0.53) | GRIN1GRIN2B | |
| SCHEMBL11244626 | 0.73 | PDE3B (0.49) | PDE3BPDE3AGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |