Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 11/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246666 | 0.91 | CASP1 (0.44) | CASP1CDC7MAPTCHUKMAP2K3 | |
| SCHEMBL11247865 | 0.89 | MAPT (0.41) | MAPTTP53THRBGSK3B | |
| SCHEMBL11241921 | 0.88 | KDM4E (0.44) | CASP1MAPTTP53THRBGSK3B | |
| SCHEMBL11237167 | 0.86 | CASP1 (0.48) | CASP1CDC7MAPTCHUKTP53 | |
| SCHEMBL11245569 | 0.84 | CASP1 (0.46) | CASP1CDC7MAPTCHUKTP53 | |
| SCHEMBL11230793 | 0.83 | CASP1 (0.53) | CASP1CDC7MAPTGSK3B | |
| SCHEMBL11246951 | 0.82 | CASP1 (0.47) | CASP1CDC7MAPTCHUKMAP2K3 | |
| SCHEMBL11239303 | 0.82 | AURKB (0.44) | CASP1CDC7MAPTMAP2K3TP53 | |
| SCHEMBL11246144 | 0.81 | CASP1 (0.48) | CASP1CDC7MAPTCHUKMAP2K3 | |
| SCHEMBL11245678 | 0.80 | CASP1 (0.45) | CASP1CDC7MAPTCHUKTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |