Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 9/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236627 | 0.88 | CCR1 (0.40) | GAAKDM4EHPGDHSD17B10CCR1 | |
| SCHEMBL11239062 | 0.81 | KDM4E (0.50) | GAAKDM4EHPGDHSD17B10PKM | |
| SCHEMBL10989508 | 0.80 | GAA (0.49) | GAAKDM4EHPGDHSD17B10PKM | |
| SCHEMBL11231370 | 0.78 | PDE3B (0.54) | KDM4EHPGDCCR1CCR5CCR8 | |
| SCHEMBL11248742 | 0.78 | CCR1 (0.44) | KDM4EHPGDCCR1CCR5CCR8 | |
| SCHEMBL16277406 | 0.76 | DHODH (0.53) | CCR1CCR5CCR8HDAC6DHODH | |
| SCHEMBL11233196 | 0.76 | KDM4E (0.51) | GAAKDM4EHPGDHSD17B10PKM | |
| SCHEMBL11240175 | 0.75 | PDE3A (0.57) | GAAKDM4EHPGDHSD17B10CCR1 | |
| SCHEMBL10991971 | 0.74 | KDM4E (0.56) | GAAKDM4EHPGDHSD17B10PKM | |
| SCHEMBL7276070 | 0.73 | PDE3B (0.61) | GAAKDM4EHPGDHSD17B10PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4312875-A | 5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof | STERLING DRUG INC. (US) | 1982-01-26 | — | — | US | disclosed |