Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | HMOX1 | P09601 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11240312 | 0.95 | CYP2A6 (0.50) | CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6 | |
| SCHEMBL11243047 | 0.93 | CYP2A6 (0.50) | CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6 | |
| SCHEMBL11231019 | 0.88 | QPCT (0.47) | CYP19A1CYP11B1CYP11B2HMOX1ALDH1A1 | |
| SCHEMBL11245231 | 0.88 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2HMOX1 | |
| SCHEMBL11238051 | 0.88 | CYP2A6 (0.52) | CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6 | |
| SCHEMBL11234501 | 0.86 | HMOX1 (0.47) | CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6 | |
| SCHEMBL11238359 | 0.85 | HMOX1 (0.56) | CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6 | |
| SCHEMBL11244363 | 0.85 | MEN1 (0.52) | CYP19A1HMOX1ALDH1A1TP53 | |
| SCHEMBL11247504 | 0.84 | HMOX1 (0.46) | CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6 | |
| SCHEMBL11242613 | 0.83 | QPCT (0.49) | CYP19A1CYP11B1CYP11B2HMOX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |