SCHEMBL11249112

SCHEMBL11249112

N#Cc1ccc(-n2cc(C#N)c(=O)[nH]c2=O)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.47
KMT2A Q03164 3/20 0.46
MEN1 O00255 1/20 0.46
GAA P10253 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.38
PARP1 P09874 1/20 0.38
TNK2 Q07912 1/20 0.38
TNK1 Q13470 1/20 0.38
TDP1 Q9NUW8 1/20 0.35
CRHR1 P34998 1/20 0.35
CASP3 P42574 1/20 0.35
VCAM1 P19320 1/20 0.33
FASN P49327 1/20 0.33
GRIA1 P42261 1/20 0.33
CACNG8 Q8WXS5 1/20 0.33
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
HSD11B1 P28845 1/20 0.32
P2RX7 Q99572 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11257435 0.85 GAA (0.50) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL11247715 0.82 SMN1; SMN2 (0.48) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL11241946 0.82 GAA (0.51) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL11253309 0.81 L3MBTL1 (0.49) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL8888395 0.77 L3MBTL1 (0.46) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL11253313 0.77 GAA (0.50) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL11246293 0.77 L3MBTL1 (0.69) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL11260931 0.77 GAA (0.52) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL8888929 0.75 L3MBTL1 (0.59) L3MBTL1KMT2AMEN1GAASMN1; SMN2
SCHEMBL11248200 0.75 GAA (0.56) L3MBTL1KMT2AMEN1GAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4358591-A BACTERICIDES, FUNGICIDES; PLANT DISEASES ZOECON CORPORATION (US) 1982-11-09 US disclosed
US-4338318-A FUNGICIDE OR BACERICIDE TO TREAT PLANT DISEASES WITH A PHENYL URACIL ZOECON CORPORATION (US) 1982-07-06 US disclosed
US-4307098-A 2-PHENYL-URACIL COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-12-22 US disclosed
US-4297297-A α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates ZOECON CORP. (US) 1981-10-27 US disclosed
US-4266056-A FUNGICIDES, BACTERICIDES ZOECON CORPORATION (US) 1981-05-05 US disclosed