Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 7/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11234832 | 1.00 | PRSS1 (0.44) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11069895 | 0.88 | RARB (0.51) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11075874 | 0.88 | RARB (0.51) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6139653 | 0.88 | RARB (0.51) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11350271 | 0.87 | RARB (0.50) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11245590 | 0.83 | PLK1 (0.53) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11234252 | 0.83 | PLK1 (0.53) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11563318 | 0.83 | PRSS1 (0.42) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11286580 | 0.82 | PRSS1 (0.44) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11562499 | 0.82 | POLB (0.57) | PRSS1F2PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4348399-A | Antiatherosclerotic and hypolipidemic 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives | AMERICAN CYANAMID COMPANY (US) | 1982-09-07 | — | — | US | disclosed |