Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PNLIP | P16233 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11251685 | 1.00 | PLK1 (0.46) | PLK1LMNACYP1A2KDM4ECRBN | |
| SCHEMBL11313614 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL11306884 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL11307880 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL11315370 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL11318044 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL11307809 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL11313424 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL11313529 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL11319758 | 0.89 | PLK1 (0.48) | PLK1LMNACYP1A2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4333940-A | Ring-fluorinated 4-(monosubstituted-amino) phenyl compounds in inhibiting atherosclerotic lesion development | AMERICAN CYANAMID COMPANY (US) | 1982-06-08 | — | — | US | disclosed |
| US-4243609-A | ANTILIPEMIC AGENTS, ANTIATHEROSCLEROTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | disclosed |