Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.41 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.41 |
| ▸ | MCTS1 | Q9ULC4 | 3/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11247181 | 1.00 | PPARA (0.46) | PPARAPPARGMEN1MAPTKMT2A | |
| SCHEMBL11044937 | 1.00 | PPARA (0.46) | PPARAPPARGMEN1MAPTKMT2A | |
| Ammonia Solution, Strong SCHEMBL11243218 | 0.99 | PPARA (0.45) | PPARAPPARGMEN1MAPTKMT2A | |
| SCHEMBL11299144 | 0.99 | PPARA (0.45) | PPARAPPARGMEN1MAPTKMT2A | |
| Tromethamine SCHEMBL11239832 | 0.92 | MEN1 (0.42) | PPARAPPARGMEN1MAPTKMT2A | |
| Potassium Ion SCHEMBL11245683 | 0.89 | PPARA (0.43) | PPARAPPARGMEN1MAPTKMT2A | |
| SCHEMBL11248105 | 0.89 | MEN1 (0.46) | PPARAPPARGMEN1MAPTKMT2A | |
| SCHEMBL11299139 | 0.89 | PPARA (0.43) | PPARAPPARGMEN1MAPTKMT2A | |
| SCHEMBL11238172 | 0.89 | PPARA (0.43) | PPARAPPARGMEN1MAPTKMT2A | |
| SCHEMBL4130175 | 0.86 | ALDH1A1 (0.44) | MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009306-B1 | ANTI-ARTHRITIC HYDROXYACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESSES FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-11-24 | — | — | EP | disclosed |
| US-4310544-A | Hydroxyacetic acid derivatives with anti-arthritic properties | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-01-12 | — | — | US | disclosed |
| EP-0009306-A1 | Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-04-02 | — | — | EP | disclosed |