Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 11/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11252969 | 0.87 | OPRL1 (0.48) | OPRL1OPRM1OPRK1HTR2AHRH1 | |
| SCHEMBL11255411 | 0.86 | HPGD (0.43) | OPRM1OPRK1HTR2AHRH1HPGD | |
| Bromide SCHEMBL11441013 | 0.85 | HPGD (0.42) | OPRM1OPRK1HTR2AHRH1HPGD | |
| Bromide SCHEMBL11433552 | 0.83 | HTR2A (0.41) | OPRM1OPRK1HTR2AHRH1HPGD | |
| Bromide SCHEMBL11428282 | 0.83 | HTR2A (0.53) | OPRK1HTR2AHRH1HPGDL3MBTL1 | |
| SCHEMBL11431396 | 0.83 | HTR2A (0.41) | OPRM1OPRK1HTR2AHRH1HPGD | |
| Bromide SCHEMBL11242155 | 0.82 | HPGD (0.40) | OPRM1OPRK1HTR2AHRH1HPGD | |
| SCHEMBL11441053 | 0.82 | SIGMAR1 (0.53) | OPRM1OPRK1HTR2AHRH1HPGD | |
| SCHEMBL11247919 | 0.82 | HRH1 (0.48) | OPRM1OPRK1HTR2AHRH1HPGD | |
| Bromide SCHEMBL11258479 | 0.81 | HRH1 (0.47) | OPRM1OPRK1HTR2AHRH1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013424-B1 | SPIRO(DIBENZO(B,F)THIEPINE-PIPERIDINES), INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | claimed |
| EP-0013424-A1 | Spiro(dibenzo(b,f)thiepine-piperidines), intermediate products for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | claimed |
| US-4198420-A | Spiro[dibenz(b,f)thiepin-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | claimed |