Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 18/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11249876 | 0.90 | ADRB2 (0.69) | ADRB2ADRB1ADRB3GLAADRA1D | |
| SCHEMBL4256482 | 0.85 | ADRB2 (0.67) | ADRB2ADRB1ADRB3GLA | |
| SCHEMBL10895573 | 0.85 | ADRB3 (0.83) | ADRB2ADRB1ADRB3GLAADRA1D | |
| SCHEMBL10661675 | 0.83 | ADRB2 (0.66) | ADRB2ADRB1ADRB3 | |
| SCHEMBL4386774 | 0.83 | ADRB2 (0.66) | ADRB2ADRB1ADRB3 | |
| SCHEMBL4386778 | 0.83 | ADRB2 (0.66) | ADRB2ADRB1ADRB3 | |
| SCHEMBL14422857 | 0.81 | ADRB2 (0.61) | ADRB2ADRB1ADRB3GLAADRA1A | |
| SCHEMBL4384732 | 0.81 | ADRB2 (0.71) | ADRB2ADRB1ADRB3 | |
| SCHEMBL4256480 | 0.81 | ADRB2 (0.74) | ADRB2 | |
| SCHEMBL14422860 | 0.81 | ADRB2 (0.80) | ADRB2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | claimed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| EP-0023385-A1 | Ethanamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-02-04 | — | — | EP | disclosed |