Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260056 | 0.88 | PLAU (0.43) | PLAUEPHX1EPHX2MAPTNPC1 | |
| SCHEMBL4100753 | 0.86 | EPHX1 (0.58) | EPHX1EPHX2MAPTNPC1KDM4E | |
| SCHEMBL27544704 | 0.84 | NPC1 (0.55) | PLAUEPHX1EPHX2MAPTNPC1 | |
| SCHEMBL6701331 | 0.82 | MAPT (0.60) | EPHX1EPHX2MAPTNPC1KDM4E | |
| SCHEMBL4103669 | 0.82 | SLC2A1 (0.56) | MAPTNPC1KDM4ERAB9AMEN1 | |
| SCHEMBL11253879 | 0.82 | PLAU (0.46) | PLAUEPHX2NPC1RAB9AMEN1 | |
| SCHEMBL11250207 | 0.82 | PLAU (0.36) | PLAUMAPT | |
| SCHEMBL11245874 | 0.79 | KDR (0.50) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL11263019 | 0.79 | HTT (0.56) | PLAUEPHX1EPHX2NPC1KDM4E | |
| SCHEMBL11093176 | 0.79 | CYP1A2 (0.45) | PLAUEPHX1EPHX2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |