Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 6/20 | 0.45 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742985 | 0.86 | KDR (0.57) | KDRPDK1FLT1TMPRSS4GRM4 | |
| SCHEMBL11259118 | 0.84 | KCNQ3 (0.45) | KDRPDK1TMPRSS4GRM4HTT | |
| SCHEMBL4100753 | 0.83 | EPHX1 (0.58) | GRM4MEN1HTTKMT2ANPSR1 | |
| SCHEMBL11254366 | 0.83 | MAPT (0.47) | KDRPDK1TMPRSS4MEN1HTT | |
| SCHEMBL4103669 | 0.82 | SLC2A1 (0.56) | MEN1HTTKMT2ANPSR1CA2 | |
| SCHEMBL11263943 | 0.82 | HTT (0.46) | KDRPDK1FLT1TMPRSS4MEN1 | |
| SCHEMBL11257942 | 0.81 | HTT (0.58) | KDRPDK1MEN1HTTKMT2A | |
| SCHEMBL4556067 | 0.80 | KDR (0.75) | KDRPDK1MEN1HTTKMT2A | |
| SCHEMBL6699635 | 0.79 | MAOB (0.47) | MEN1KMT2ANPC1MAPTRAB9A | |
| SCHEMBL11253702 | 0.79 | PLAU (0.46) | MEN1KMT2ANPSR1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |