Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255248 | 1.00 | MAPT (0.52) | MAPTMAPK1NLRP3RECQLKMT2A | |
| Peraclopone SCHEMBL11255181 | 0.83 | KDM4E (0.53) | MAPTMAPK1RECQLKMT2AGAA | |
| Peraclopone SCHEMBL2110307 | 0.83 | KDM4E (0.53) | MAPTMAPK1RECQLKMT2AGAA | |
| Peraclopone SCHEMBL11255188 | 0.83 | KDM4E (0.53) | MAPTMAPK1RECQLKMT2AGAA | |
| Peraclopone SCHEMBL11251959 | 0.82 | KDM4E (0.52) | MAPTMAPK1RECQLKMT2AGAA | |
| Peraclopone SCHEMBL11266970 | 0.82 | KDM4E (0.52) | MAPTMAPK1RECQLKMT2AGAA | |
| Peraclopone SCHEMBL11251964 | 0.82 | KDM4E (0.52) | MAPTMAPK1RECQLKMT2AGAA | |
| Peraclopone SCHEMBL11266972 | 0.82 | KDM4E (0.52) | MAPTMAPK1RECQLKMT2AGAA | |
| Hydrochloric Acid SCHEMBL11266253 | 0.77 | MAPT (0.64) | MAPTMAPK1KMT2AGAAMEN1 | |
| Hydrochloric Acid SCHEMBL11247700 | 0.74 | TSHR (0.57) | MAPTMAPK1KMT2AGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4358450-A | FOR DECREASING BLOOD CHOLESTEROL | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-09 | — | — | US | claimed |
| US-4358450-A | FOR DECREASING BLOOD CHOLESTEROL | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-09 | — | — | US | disclosed |